Juvenile idiopathic arthritis is the most common persistent arthritis in children. The initial symptoms are not specific, including lethargy, tiredness and poor appetite (which may be caused by drugs). Especially in young children, the biggest manifestation may be limping, and children may have severe influenza-like manifestations.
The disease often occurs in knee joint, ankle joint, wrist joint and facet joint of hands and feet, and its cause is still unknown as its name [idiopathic].
Antibiotics Increase Risk of Idiopathic Arthritis in Children
Studies have confirmed that the application of antibiotics in children can significantly increase the risk of juvenile idiopathic arthritis in a dose-dependent manner, i.e. The risk increases with the increase of administration times.
With more knowledge of microbiology, people have found that microorganisms play an important role in a series of diseases, such as autoimmune diseases, including inflammatory bowel disease, rheumatoid arthritis and psoriatic arthritis, which have many similarities with juvenile idiopathic arthritis.
Changes in intestinal flora caused by antibiotic use seem to be one of the causes of juvenile idiopathic arthritis. If the normal flora environment changes, some of these bacteria will promote inflammatory reactions, while others may cause anti-inflammatory reactions.
If people inadvertently change the microbial environment and lead to an increase in pro-inflammatory bacteria, it may potentially lead to arthritis and other autoimmune diseases.
Another reason to avoid antibiotics
However, the fact is that the exact cause of childhood idiopathic arthritis in children is still unclear, and antibiotics are very effective drugs in some cases.
Then, it can only be emphasized that antibiotic treatment should be given carefully. If children are given antibiotics without bacterial infection, children will not only use unnecessary drugs, but also lead to an increased risk of antibiotic resistance and [potential arthritis risk] described in this article.