Do test tube baby, how to do embryo implantation failure after transplantation?

Many couples have fulfilled their wish to ask for children through IVF, but some people have failed to conceive children smoothly and embryo implantation has failed.

Why is this?

There is something wrong with the embryo itself.

Whether the embryo is healthy or not directly affects the success rate of transplantation.

Of course, we will try our best to choose the [best] embryos before transplantation to improve the success rate. At present, we can judge the quality of embryos by [embryo score].

However, the quality score of embryos is mainly concentrated on [appearance], and it can only be said that embryos with [high score] have a greater chance of successful implantation than embryos with [high score].

Because only observing the morphology of the embryo cannot obtain important information such as chromosomes and genes of the embryo, nor can it fully evaluate the developmental potential of the embryo. Therefore, even the so-called “high-quality embryo” cannot guarantee 100% success.


At present, blastocyst transfer is mainly adopted.

Blastocysts are further screened embryos, and the success rate of implantation is higher. Therefore, patients who have failed to transfer many times can obtain more embryos and improve the success rate by culturing blastocysts and retransferring them.

There is something wrong with my mother’s health.

The process of embryo implantation is like planting crops. To harvest fruits, one must not only have good seeds, but also have good soil and nutrition supply.

Seeds refer to healthy embryos and soil refers to endometrium. To ensure nutrition supply, mothers need to keep healthy.

Therefore, if the mother has the following problems, the embryo implantation will fail.

1. Endometrial abnormalities

The endometrium is in good condition, indicating that the soil is fertile enough to accept the embryo as a seed. If the endometrium is too thin, or there are polyps, adhesions and other conditions, it is not conducive to embryo implantation.


Under the guidance of doctors, oral estrogen and other methods can improve the thickness of the intima to meet the needs.

Hysteroscopy can find out endometrial polyps, intrauterine adhesions, etc. Once found, doctors will remove polyps and separate adhesions according to the disease condition.

2. Endocrine abnormalities

Common endocrine abnormalities include thyroid dysfunction (hyperthyroidism, hypothyroidism and other diseases), hyperprolactinemia and other conditions.


Targeted treatment of thyroid diseases and restoration of thyroid function. For example, [hyperthyroidism] should appropriately reduce the level of thyroid hormone, while [hypothyroidism] should appropriately increase the level of thyroid hormone.

Under the guidance of doctors, oral bromocriptine can treat hyperprolactinemia.

3. Coagulation dysfunction

Common coagulation abnormalities include antiphospholipid antibody syndrome and coagulation factor abnormalities, which easily lead to local blood supply insufficiency of endometrium and affect embryo implantation.


Under the guidance of doctors, oral aspirin and injection of low molecular weight heparin can be treated.

4. Immune dysfunction

During embryo implantation, if the mother’s immune function is abnormal (such as abnormal increase of natural killer cell activity, abnormal secretion of local immune antibodies, etc.), repeated implantation failure may be caused.


This kind of problem is more troublesome to deal with and can be treated by infusion of high doses of immunoglobulin or husband’s lymphocytes, but it is not useful for everyone.

The reasons for the failure of embryo implantation after transplantation are very complicated, but we should not be discouraged or put too much pressure on ourselves.

Cooperate with doctors to do a good job of examination and analysis of the causes, usually can find countermeasures, maybe the next time will be successful!