I believe everyone knows that taking medicine to reduce uric acid is very important for gout treatment. If uric acid cannot be lowered for a long time, gout will easily occur frequently and even gout stones will appear everywhere in the body, resulting in joint deformation and kidney damage.
However, uric acid reduction therapy is a long marathon race, and the emphasis is on persistence.
In order to make the patients, with the right strength, take fewer detours and suffer less. I hope you can do the following two things when taking medicine to reduce uric acid.
Lowering uric acid should be stable, not too fast.
When many patients see the uric acid value marked with the “upward arrow” on the test form, they always want to know how to make the uric acid drop quickly. I wish I could take the uric acid lowering medicine today and go to the test tomorrow, and the [arrow] will disappear.
[Rapid Uric Acid Reduction] It looks beautiful, but it is extremely easy to lead to gout attacks. In the short term, the main cause of gout attacks is usually not high uric acid, but violent fluctuations in uric acid levels, including sudden increases and decreases.
When uric acid suddenly decreases, the original urate crystals in joints and other places will dissolve rapidly, producing some [microcrystals]. It is these [microcrystals] that stimulate joints and lead to gout attacks. See here, some patients may suddenly realize [no wonder when taking uric acid lowering drugs, gout will also attack].
In fact, uric acid lowering therapy itself may cause acute gout attacks. Moreover, the stronger the effect of uric acid lowering drugs, the greater the possibility of inducing gout attacks.
Due to different physical conditions and different reactions to drugs, it is possible that conventional doses of drugs will cause uric acid to drop rapidly. At this time, it is even more important to add small doses of drugs such as colchicine to prevent gout attacks.
Lowering uric acid should be moderate, not too low.
Gout can be regarded as a [advanced disease]. Animals lower than us do not suffer from gout because they have uricase, which can break down uric acid. This is why tigers do not suffer from gout after eating half a sheep at a time, while many gout patients may suffer from gout attacks after drinking beer.
In the process of human evolution, human beings have lost the gene of enzyme that can decompose uric acid, and maintaining a certain level of uric acid is actually beneficial to human body. Some studies have found that blood uric acid can activate the immune system of human body to a certain extent, while the blood uric acid level of Alzheimer’s disease patients (commonly known as senile dementia) is lower than that of non-sick people.
Although in the treatment of lowering uric acid, we emphasize to reduce uric acid to the target value, patients without tophus to below 360 mol/L and patients with tophus to below 300 mol/L, we also do not advocate lowering uric acid too low, which is close to the target value.