Is there finally a magic drug to end AIDS infection?

On 30 July 2015, U.S. President Barack Obama Signed Presidential Decree, Release the HIV/AIDS Strategy for the next five years. In fact, The new version of the plan is not much different from the old version, We will still focus on and hope for a drug [capable of preventing HIV infection]-Truvada. Truvada’s past lives said Truvada, Mention cannot be made of pre-exposure HIV prevention measures, This refers to the daily use of antiretroviral drugs by people who are not infected with HIV. To prevent HIV infection, Pre-exposure prophylaxis in serologically inconsistent heterosexual partners (one of whom is infected, The other side does not), men who have sex with men, transgender people, high-risk heterosexual partners and injecting drug users can effectively reduce HIV transmission. WHO supports attitudes and encourages countries to carry out projects. As early as 2012, Truvada, It is approved by the U.S. Food and Drug Administration for listing. This drug can be combined with [pre-exposure prophylaxis], PrEP). Mixed reviews. Truvada’s reputation, It has always been mixed. According to some studies, After taking Truvada daily, It can reduce the possibility of HIV infection by at least 92%. U.S. Health officials also strongly recommend people at high risk of HIV to take this drug. However, the negative view is that, The advent of this drug will gradually make people forget the panic and disaster brought by AIDS. It may even lead to a more promiscuous concept of sexual freedom. In addition, what will only take this drug about how it works and how safe it is. Even the debate and slander about whether it should be put into the market are gradually spreading. In fact, Truvada’s actual usage rate is far lower than expected. According to statistics from Gilead, Truvada’s research and development company: Since the FDA approved Truvada’s listing, Clinicians only prescribed the drug for HIV prevention in 8,512 people, At present, there are still about 50,000 new HIV infections in the United States every year. Six declassifications are to break and clarify various rumors circulating in the society. Let people scientifically understand this drug that may change the current AIDS epidemic situation. Next, let professionals declassify it for us from six aspects [ Pre-exposure prevention] (PREP) and Truvada are magical drugs. 1. Pre-exposure prevention is not foolproof even if medication is strictly followed by the doctor’s advice. However, even if the drug is occasionally missed once or twice, The efficacy of the drug will not be completely lost. Some readers may think this is nonsense… but in fact, What experts emphasize here is only three words-[compliance]. To put it more popularly, In other words, it refers to whether the individual can strictly follow the doctor’s advice and take drugs on time. The US Centers for Disease Control and Prevention recommends clinicians to prescribe one tablet a day. If taken strictly at this dose, The success rate of pre-exposure prevention is almost 92%. But whether everyone will take the medicine on time and quantitatively, But it is difficult to count clearly. Its curative effect will naturally be greatly reduced. 2. There is no evidence to show that, The use of pre-exposure prevention will make individuals more vulnerable to high-risk sexual behaviors. In fact, The initial resistance to the introduction of Truvada was due to the view that, The introduction of this drug will lead to the proliferation of high-risk sexual behaviors and the reduction of condom use. Among them, There were even criticisms from Michael Weinstein, president of the Los Angeles AIDS Health Foundation, the largest HIV/AIDS medical institution in the United States. He thinks Truvada is a [party drug], Its promotion and use will only lead to more people having non-condom sexual intercourse or non-condom anal intercourse. But in fact, According to a survey by Grinder, a same-sex social software, Pre-exposure prevention does not change the attitude of homosexual individuals towards high-risk sexual behaviors. In other words, Whether Truvada comes out or not, People who are involved in high-risk sex do not care. 3. Pre-exposure prevention does not cause virus mutation. Producing drug-resistant HIV virus. In fact, The idea of virus mutation is simply nonsense. Simply put, it is: No HIV infection, What about drug resistance? Pre-exposure prevention is only applicable to individuals who have negative HIV tests. In other words, there is no virus in their bodies to develop drug resistance to Truvada. In clinical trials of pre-exposure prevention, There were indeed several cases of drug resistance. But in the end, it was found that these subjects were actually infected with HIV virus. In other words, They were infected days or weeks before the HIV test, So the test results were negative. Therefore, Some people in the incubation period of HIV infection may be prescribed with pre-exposure prophylaxis drugs, And eventually lead to drug-resistant viruses. But in fact, Its occurrence probability is extremely low, The receiving doctor can basically have problems quickly, And deal with it. 4. Individual particularity cannot be ignored. Researchers have conducted about 35 demonstration projects on drug use worldwide. A sample was used to test the actual use of Truvada in real life among people at high risk of HIV exposure. Among the participants in the study, mainly heterosexual men and women from Botswana, Young black men in the Gulf of California, people injecting drugs in Thailand, women and transgender sex workers in India, and serologically differentiated couples with stable relationships (HIV positive and negative respectively) in Nigeria. In the study conducted in each region, The distribution rate of drugs should not be lower than the local HIV infection rate. At the same time, Because of the complexity and particularity of the research, This also requires researchers in each region to do their best to conduct visits and surveys to obtain research data. However, in practice, Researchers have encountered many difficulties. For example, In the United States, young black men and Latino men are less likely to accept and take Truvada than other groups. However, in fact, the HIV infection rate in these two groups is higher than that in other groups. In these studies, They also found that black men had lower-than-average compliance. They speculated that, This may be related to false rumors about drugs, unfair treatment of them and other social factors. 5. Pre-exposure prevention does not prevent other sexually transmitted diseases. Pre-exposure prevention methods do not prevent many diseases like condoms. It is useful for only one disease, That is, HIV infection plays a preventive and protective role. Those who use Truvada still need to actively prevent the threat of other sexually transmitted diseases. In some studies, No matter before or during the study, The prevalence of sexually transmitted diseases has remained at a high level of 25%. Therefore, If you want to get the most complete protection measures, Especially for those who do not know the status of their sexual partners’ sexually transmitted infections, Using both Truvada and condoms is the best choice. In other words, No method is omnipotent, One more layer of protection and one more set of methods will always be better. 6. Prevention before exposure does bring some side effects. But it’s all under control. It’s a three-part drug, Truvada, as a drug, There are also some side effects. The most common ones are nausea (which occurs in about 5% of individuals after taking the medicine), abdominal pain, vomiting, dizziness, fatigue and diarrhea. However, most symptoms will disappear naturally after taking the medicine for one month. Relevant reports said: When some HIV-positive patients take Truvada and other drugs at the same time, Bone loss and renal damage, So some people worry that Truvada will have these side effects. But in fact, At present, the above side effects caused by taking Truvada have not been found in healthy people. Therefore, In clinical use, Doctors should inform patients about the side effects of taking drugs. But as far as the current observation is concerned, There are no serious side effects, so there is no need to panic about them. But experts also said that pre-exposure prevention should not last for life like HIV treatment. In other words, drugs should be taken during periods when high-risk sexual behaviors may exist, instead of taking such drugs for life like patients.