Those antipyretics that should be eliminated

Yesterday morning, I sent a microblog to tell everyone that analgin has been eliminated abroad, so some netizens commented under the microblog: “I have relied on it to reduce my fever only a few times since I was a child, and the effect is quick and cheap], while others commented:” I went to a large 3A hospital to see a doctor, and the doctor gave my baby analgin nasal drops. “

There is a long way to go in popular science, Not only does the general public need to update their knowledge of medication, Clinicians need to update their knowledge of medication. The basic principles of scientific medication are safety, effectiveness and economy. Safety is ranked first. When the use of a drug is no longer safe, elimination is inevitable. Quick and cheap results cannot be used as a reason to continue to eat it. Here, let’s talk about those antipyretics that should be eliminated.


Analgin has been used as an antipyretic since the 1920s. In 1977, The United States officially banned analgin, And withdraw the drug from the U.S. Market. At present, the drug is banned in more than 30 countries around the world. It has been eliminated as an antipyretic because it may cause serious adverse reactions. These serious adverse reactions include: causing fatal granulocytopenia, autoimmune hemolytic anemia and aplastic anemia; The skin can cause urticaria, Exfoliative dermatitis may occur in severe cases, Epidermolysis bullosa. Commonly used drugs containing analgin and Chongganling, It should also be eliminated. The above three types of drugs contain aminopyrine and phenacetin. From 1922 to 1934, Aminopyrine, as a new antipyretic, is popular in Europe and the United States. However, in the process of using this drug, it has been found that patients taking this drug have stomatitis, sore throat and other symptoms. After laboratory tests, it was found that the patient’s granulocytopenia, It is proved that aminopyrine can cause severe granulocytopenia, Causing a decline in immunity, And caused various infections. In 1938, The United States decided to remove aminopyrine from the list of legal drugs. In Denmark, The drug has been completely banned since the 1930s. It has not been found in the current U.S. Pharmacopoeia (USP34-NF29), European Pharmacopoeia (EP6.0) and Japanese Pharmacy JP16. Phenacetin was also a widely used antipyretic. After 1953, Many European countries, In particular, Switzerland, West Germany and other countries have found a large increase in kidney patients. After investigation, it was confirmed that the increase in kidney disease was mainly caused by taking phenacetin. These countries have taken urgent measures, After banning the sale of drugs containing phenacetin, The number of patients with this type of kidney disease has decreased significantly. Nimesulide nimesulide is an anti-inflammatory drug, It has anti-inflammatory, analgesic and antipyretic effects. At the beginning of its market, this drug was used to treat chronic arthritis. Pain and fever. But in recent years, There have been many reports of adverse reactions to severe liver damage related to the use of nimesulide worldwide. In combination with these adverse reactions, the drug is currently prohibited from being used as an antipyretic and children under 12 years old. It is only used as a second-line anti-inflammatory analgesic, i.e. When at least one other anti-inflammatory drug fails to be treated. It is limited to the treatment of chronic arthritis pain, pain after surgery and acute trauma, and primary dysmenorrhea. After saying that the above antipyretic should be eliminated, I guess you would like to know which drugs can be used to reduce fever. Now let me tell you, At present, there are two kinds of safe and cheap antipyretic drugs widely used in the world: [acetaminophen and ibuprofen]. As to whether fever should be reduced as soon as possible, what should only take antipyretic drugs, and how to take antipyretic drugs, I recommend you to read carefully my previous articles on rational use of antipyretic drugs.