What are the noteworthy side effects of antidepressants?

Depression is like the common cold, More and more popular, Reports of such and such celebrities suffering from depression keep popping up. In the treatment of depression, Drugs are a very important part. Today, Let’s talk about the side effects of medication for depression. Clinically, Depression patients often complain, After taking the medicine, symptoms such as nausea, diarrhea, anxiety, dizziness, drowsiness, headache, insomnia, dry mouth, constipation, blurred vision and so on occur. Generally speaking, Gradually increase the drug dose to the therapeutic dose, take the drug after meals, Can make these side effects less. After all, Side effects also reflect that the drug is taking effect, Unfortunately, The efficacy of antidepressants usually begins to be felt by patients in about two weeks. Therefore, At the beginning of the medication, Discomfort can seem intolerable. Many patients, It was also at this stage that he gave up treatment. This is a pity. In fact, If the above symptoms are really uncomfortable and do not disappear for a week, You can see a doctor immediately and adjust the medicine in time. Usually after the first two weeks, The body slowly adapts, These symptoms are less obvious. However, Some special side effects brought by drugs, Often unacceptable, Some of them may even threaten their health and life safety if they are not dealt with. The following doctor clove will talk about it. The special side effects that antidepressants may bring. 1. Sexual dysfunction Although sexual dysfunction itself is a symptom of depression, However, some studies have found that As many as 70% ~ 80% of patients have sexual dysfunction after taking medicine, Such as decreased libido, loss of pleasure and delayed ejaculation. However, Only a few patients voluntarily inform doctors. Almost all antidepressants may cause sexual dysfunction, Paroxetine, fluvoxamine, sertraline, fluoxetine and siprialin are especially obvious. Sex life is closely related to quality of life. If this change has a significant impact on the couple’s life during medication, You can find the attending doctor to adjust the medicine, such as bupropion, mirtazapine, nefazolidone, Or use other drugs to treat sexual dysfunction. 2. Suicide risk fluoxetine, paroxetine and other drugs, The antidepressant effect is slow to take effect, It usually takes 2-4 weeks, This may lead to reduced patient compliance, And increases the risk of suicide. Therefore, This risk is especially likely to occur in the early stage of medication, The patient’s family should be closely watched. If there are any signs of suicide, Family members must immediately inform the attending doctor, So that doctors can adjust the treatment plan in time. For depression patients who have suicidal ideas or have tried to commit suicide, Doctors will choose drugs or therapies that take effect faster. 3. Weight changes affect most young people, Especially for young women, The effect of weight gain on appearance is closely related to their medication compliance. Even if the weight gain is only 2 kg, It may also be enough to stop the patient by himself. Some antidepressants can increase appetite, change sugar metabolism, Mirtazapine, amitriptyline, imipramine and other drugs have obvious side effects of weight gain. Doctors usually consider this effect when prescribing drugs, Therefore, it will be explained to the patient. If this kind of situation is discovered only after taking medicine, and the reality of rapid weight gain cannot be accepted, it is better to go to the attending doctor as soon as possible and take drugs that do not have such great influence on weight. In addition, fluoxetine may cause weight loss temporarily, so it can be used to better treat eating disorders. Bupropion also has weight loss effects, Sertraline also rarely causes weight gain, Therefore, they are more suitable for the treatment of depression in overweight patients. 4. Sedative effect Paroxetine, mirtazapine, amitriptyline, trimeimipramine and other drugs have stronger sedative effects in antidepressants. It is easier to feel sleepy after eating, Taking it before going to bed can help improve sleep. In addition, Sertraline, sipralin, venlafaxine and other drugs may also have side effects that cause drowsiness. Therefore, After taking the medicine, it is more dangerous to work in the workshop and drive, If you find yourself sleepy after eating, It is better to eat at night. In addition, fluoxetine’s drowsiness effect is relatively weak and can be taken during the day. 5. Blood pressure change is the most noticeable side effect of venlafaxine, which is related to dosage, but there are also reports that low-dose blood pressure continues to rise, so hypertension patients need to use this drug with caution. If the dosage of venlafaxine is large, it is necessary to monitor blood pressure at ordinary times. If there is persistent hypertension, You need to consider dressing change. Besides, Amitriptyline, imipramine, clomipramine, trazodone and other drugs, Orthostatic hypotension is more likely to occur after taking it, That is to say, squatting down and standing up is easy to feel dizzy or even fall to the ground. This may also occur in a few patients taking mirtazapine. Therefore, it is necessary to monitor blood pressure when taking these drugs. When getting up or moving, you need to move slowly. If the blood pressure drops obviously, See a doctor in time. 6. Other physical reactions suddenly stop taking paroxetine, venlafaxine, There may be a serious withdrawal reaction, Simply put, dizziness, headache, sensory abnormalities, nausea, diarrhea, insomnia and excitement occur after stopping the drug. However, When taking these two drugs, As long as the medicine is reduced slowly according to the doctor’s advice, Generally, there will be no big problems. It should be specifically noted that, [Withdrawal reaction] is different from [drug dependence]. There are a few patients, After taking mirtazapine, neutrophilic granulocytosis may occur, And some infectious diseases have occurred. In this case, Communicate with the doctor in time and observe closely. When necessary, Blood routine can be monitored according to doctor’s advice. In the past, Some old antidepressants can cause a series of serious side effects, It is called [5-HT syndrome], It is rarely used now. However, When several antidepressants are used in combination, There is still a small possibility of this happening. It is mainly manifested as nausea, vomiting, abdominal pain, facial flushing, hyperhidrosis, tachycardia, dysphoria, agitation, tremor, hyperreflexia of tendon and increased muscle tension. The progression of the disease may cause life danger. In this case, It is necessary to stop the drug in time and deal with it urgently by the physician. Finally, I have to mention that some patients may be more worried after understanding the side effects of the antidepressants used. Don’t worry, if you can return to the clinic in time, communicate with your attending doctor on schedule, and change the attending doctor infrequently, the above side effects will not pose a threat.