Every friend with hypertension knows that it is very important to take medicine on time. How to calculate on time? Most of the drugs, what when take better effect?
Now let’s understand this problem and talk about some other drugs by the way.
Antihypertensive drugs are taken in what, according to the change of blood pressure. Generally speaking, people’s blood pressure fluctuates in a state of [two peaks and one valley] within 24 hours:
- The two peaks are the highest at 9: 00 ~ 11: 00 and 16: 00 ~ 18: 00. Yigu: It began to decline slowly from 18: 00 to the lowest from 2: 00 to 3: 00 a.m. the next day.
The blood pressure change curve in a day is like a spoon, which is called [spoon blood pressure]. According to this rule, the time of using antihypertensive drugs is also exquisite:
- Antihypertensive drugs (including controlled-release tablets and sustained-release tablets) taken once a day are usually taken at 7:00 a.m. Take antihypertensive drugs twice a day, preferably at 7: 00 a.m. and 14: 00 p.m.
The time when the drug works coincides with the two peak periods of blood pressure fluctuation.
This is based on the blood pressure changes of most people. There are also many hypertension patients whose blood pressure fluctuation is not the “spoon type” mentioned earlier, but the “reverse spoon type” with high night and low morning. In this case, you can choose to take medicine before going to bed or carry out 24-hour blood pressure monitoring to find out your own blood pressure peak and take medicine 2 hours before the highest blood pressure appears to ensure safety.
There is also a class of antihypertensive drugs called receptor blockers (such as terazosin and doxazosin), which may be used by hypertensive patients with prostatic hyperplasia. This drug will cause postural hypotension. Due to more activities during the day, in order to avoid hypotension during standing, walking and other activities, it is better to take drugs before going to bed.
In addition to antihypertensive drugs, hypertension patients may also take lipid-lowering drugs, aspirin, etc.
Statins
This is the most commonly used lipid-regulating drug, commonly called XX statin, which reduces cholesterol in blood by hindering the synthesis of cholesterol in liver. Since cholesterol is mainly synthesized at night, it is more effective to administer it at night than during the day.
For example, simvastatin, fluvastatin, lovastatin, atorvastatin calcium, etc., taking medicine at night is better than taking medicine three times a day.
Anti-angina drugs
The peak of angina pectoris attack is from 6: 00 a.m. to 12: 00 a.m., and the curative effect of drugs for angina pectoris also has circadian rhythm.
Generally speaking, calcium antagonists (commonly called XX dipine), nitrate esters, receptor blockers (commonly called XX prolol) are used in the morning, which can obviously dilate coronary arteries and improve myocardial ischemia, and the intensity of action taken in the afternoon is weakened. Therefore, angina pectoris patients had better take anti-angina pectoris drugs immediately when they wake up in the morning.
As amlodipine and lisinopril take effect smoothly, when used for the treatment of chronic stable angina pectoris, they can be administered before going to bed at night, so that the peak blood drug concentration can appear in the morning of the next day, thus better exerting the anti-angina pectoris effect.
Aspirin
Aspirin is an antiplatelet drug and plays an important role in preventing coronary heart disease and stroke. Some hypertension patients also need to take aspirin.
Most patients take aspirin once a day, either in the morning or at night, and it is best to take it at the same time every day. If it is ordinary aspirin, it can be taken before or after meals, depending on whether the gastrointestinal tract is good or not. If the gastrointestinal tract reaction is relatively large after taking the medicine half an hour before meals, take it again half an hour after meals.
At present, aspirin enteric-coated tablets are commonly used clinically, which have less irritation to gastrointestinal tract and should be taken before meals.
Knowing this, do you know more about the medicine you have on hand?